An antagonist of growth hormone-releasing hormone protects against LPS-induced increase of bronchoalveolar lavage fluid protein concentration.
Mohammad S AkhterKhadeja-Tul KubraMohammad A UddinSeetharama JoisNektarios BarabutisPublished in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2022)
Growth Hormone-Releasing Hormone (GHRH) is a neuropeptide regulating the release of Growth Hormone (GH) from the anterior pituitary gland, and acts as a growth factor in a diverse variety of tissues. GHRH antagonists (GHRHAnt) have been developed to counteract those events, and the beneficial effects of those peptides toward homeostasis have been associated with anti-inflammatory activities. Our lab is interested in delineating the mechanisms governing endothelial barrier function. Our goal is to establish new grounds on the development of efficient countermeasures against Acute Respiratory Distress Syndrome (ARDS), which has been associated with thousands of deaths worldwide due to COVID-19. Herein we demonstrate in vivo that GHRHAnt suppresses LPS-induced increase in bronchoalveolar lavage fluid (BALF) protein concentration, thus protecting the lungs against edema and inflammation.
Keyphrases
- growth hormone
- lps induced
- acute respiratory distress syndrome
- growth factor
- inflammatory response
- extracorporeal membrane oxygenation
- mechanical ventilation
- anti inflammatory
- amino acid
- sars cov
- coronavirus disease
- protein protein
- oxidative stress
- signaling pathway
- endothelial cells
- small molecule
- respiratory syndrome coronavirus