N-Glycan Profile and Kidney Disease in Type 1 Diabetes.
Mairead L BerminghamMarco ColomboStuart J McGurnaghanLuke A K BlackbournFrano VučkovićMaja Pučić BakovićIrena Trbojević-AkmačićGordan LaucFelix AgakovAnna S AgakovaCaroline HaywardLucija KlarićColin N A PalmerJohn R PetrieJohn ChalmersAndrew CollierFiona GreenRobert S LindsaySandra MacruryJohn A McKnightAlan W PatrickSandeep ThekkepatOlga GornikPaul M McKeigueHelen Martina Colhounnull nullPublished in: Diabetes care (2017)
Higher HbA1c in type 1 diabetes is associated with changes in the serum N-glycome that have elsewhere been shown to regulate the epidermal growth factor receptor and transforming growth factor-β pathways that are implicated in DKD. Furthermore, N-glycans are associated with ACR and eGFR slope. These data suggest that the role of altered N-glycans in DKD warrants further investigation.
Keyphrases
- epidermal growth factor receptor
- type diabetes
- transforming growth factor
- tyrosine kinase
- advanced non small cell lung cancer
- cell surface
- epithelial mesenchymal transition
- glycemic control
- cardiovascular disease
- insulin resistance
- small cell lung cancer
- electronic health record
- big data
- signaling pathway
- machine learning
- adipose tissue
- artificial intelligence