Plasma TIMP-1 as a sex-specific biomarker for acute lung injury.

Sultan AlmuntashiriTimothy W JonesXiaoyun WangAndrea SikoraDuo Zhang

Published in: Biology of sex differences (2022)

Circulating TIMP-1 appeared to be a promising biomarker for mortality among females with ARDS. The high TIMP-1 group showed worse VFDs and ICU-free days. Circulating TIMP-1 may be a sex-specific biomarker in the setting of ARDS and could improve ARDS phenotyping as well as provide a novel therapeutic target in females.

Keyphrases

acute respiratory distress syndrome
mechanical ventilation
extracorporeal membrane oxygenation
intensive care unit
cardiovascular events
high throughput
risk factors
inflammatory response