Synergism of ApoE4 and systemic infectious burden is mediated by the APOE-NLRP3 axis in Alzheimer's disease.
Xue-Ting LiuXiu ChenNa ZhaoFan GengMeng-Meng ZhuQing-Guo RenPublished in: Psychiatry and clinical neurosciences (2024)
Our study highlights the importance of NLRP3 inflammasomes in linking ApoE4 with microglia innate immune function. These findings not only provide a molecular basis for APOE4-mediated neuroinflammatory but also reveal the potential reason for the increased risk of AD in APOE4 gene carriers after contracting infectious diseases.
Keyphrases
- cognitive decline
- high fat diet
- infectious diseases
- mild cognitive impairment
- innate immune
- genome wide
- inflammatory response
- type diabetes
- gene expression
- single cell
- insulin resistance
- metabolic syndrome
- copy number
- nlrp inflammasome
- spinal cord
- risk factors
- spinal cord injury
- climate change
- dna methylation
- human health
- drug induced