Solute Transporter OCTN1/Slc22a4 Affects Disease Severity and Response to Infliximab in Experimental Colitis: Role of Gut Microbiota and Immune Modulation.

Federica Del ChiericoLetizia MasiValentina PetitoValerio BaldelliPierluigi PucaRoberta BenvenutoMarco FidaleoIvana PalucciLoris Riccardo LopetusoMaria Emiliana CaristoCinzia CarrozzaMaria Cristina GiustinianiNoritaka NakamichiYukio KatoLorenza PutignaniAntonio GasbarriniGiovambattista PaniFranco Scaldaferri

Published in: Inflammatory bowel diseases (2024)

Our data support the murine model to study OCTN1 genetic contribution to inflammatory bowel diseases. This could be the first step towards the recognition of this membrane transporter as a biomarker in inflammatory conditions and a predictor of response to therapies.

Keyphrases

ulcerative colitis
oxidative stress
electronic health record
genome wide
gene expression
dna methylation
artificial intelligence