Pharmacological inhibition of SK-channels with AP14145 prevents atrial arrhythmogenic changes in a porcine model for obstructive respiratory events.

Benedikt LinzEva Melis HesselkildeMark Alexander SkarsfeldtJulie Norup HertelStefan Michael SattlerYannan YanJacob Tfelt-HansenJonas Goldin DinessBo Hjorth BentzenDominik LinzThomas Jespersen

Published in: Journal of cardiovascular electrophysiology (2022)

In a pig model for obstructive respiratory events, the SK-channel-inhibitor AP14145 prevented INAP-associated AERP-shortening and AF-susceptibility without impairing ventricular electrophysiology. Whether SK-channels represent a target for OSA-related AF in humans warrants further study. This article is protected by copyright. All rights reserved.

Keyphrases

atrial fibrillation
transcription factor
catheter ablation
heart failure
obstructive sleep apnea
left atrial
respiratory tract
mouse model
drug induced