Salvadora persica protects mouse intestine from eimeriosis.
Saleh Al-QuraishyFelwa Abdullah ThagfanEsam Mohamed Al-ShaebiMahmood QasemRewaida Abdel-GaberMohamed Abdel Monam DkhilPublished in: Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria (2020)
Eimeriosis is a global poultry health problem. In the current study, we investigated the role of Salvadora persica leaf extracts (SE) against murine eimeriosis induced by Eimeria papillata. The infection induced an oocyst output of 6242 ± 731 oocysts/g feces. After treatment with 300 mg⁄kg SE, the oocysts expelled in feces decreased by approximately 3-fold. In addition, the total number of E. papillata in the parasitic stage decreased in the jejunum of mice after treatment with SE. In addition, SE significantly reduced the number of apoptotic cells by approximately 2-fold in the infected jejunum. SE ameliorated the changes in glutathione, malondialdehyde, and catalase due to E. papillata infection. Finally, SE regulated the cytokine genes, interleukin (IL)-1β, IL-6, interferon-γ, and tumor necrosis factor-α, and the apoptotic genes, B-cell lymphoma-2, Bax, and Caspase-3. SE protects the jejunum from E. papillata induced injury and may have potential therapeutic value as a food additive during eimeriosis.
Keyphrases
- cell death
- induced apoptosis
- high glucose
- public health
- healthcare
- rheumatoid arthritis
- diabetic rats
- mental health
- oxidative stress
- diffuse large b cell lymphoma
- signaling pathway
- immune response
- cell proliferation
- adipose tissue
- gene expression
- dendritic cells
- health information
- skeletal muscle
- atomic force microscopy
- genome wide identification
- antimicrobial resistance