Gene expression analysis of MAOA and the clock gene ARNTL in individuals with bipolar disorder compared to healthy controls.

Susanne A BengesserH HohenbergerB TropperN DalknerA BirnerF T FellendorfM PlatzerA RiegerA MagetC HammR QueissnerR PilzK BauerM LengerSabrina MorklJ Wagner-SkacelH P KapfhammerN Meier-AllardA StrackeS J HolasekL MurphyE Z Reininghaus

Published in: The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry (2021)

Clock gene expression changes were observed in different affective states of BD. More precisely, ARNTL gene expression was significantly higher in euthymia than in depression. ARNTL and MAOA gene expression correlated significantly in BD and in controls, which emphasises the strong concatenation between circadian rhythms and neurotransmitter breakdown.

Keyphrases

gene expression
bipolar disorder
dna methylation
genome wide
depressive symptoms
copy number
sleep quality