Extracellular vesicles influence the pulmonary arterial extracellular matrix in congenital diaphragmatic hernia.

Madeline N MonroeSiqin ZhaorigetuVikas S GuptaDi JinKatelyn D GivanAlexander L CuryloScott D OlsonCharles S CoxAna SeguraLouis Maximilian BujaKathryn Jane Grande-AllenMatthew T Harting

Published in: Pediatric pulmonology (2020)

These data demonstrate notable ECM remodeling in the CDH pulmonary vasculature, along with the capacity of MSC-EVs to attenuate pathological ECM remodeling, identifying MSC-EVs as a potentially efficacious therapeutic for CDH-associated pulmonary hypertension.

Keyphrases

extracellular matrix
pulmonary hypertension
pulmonary artery
pulmonary arterial hypertension
electronic health record
big data
machine learning
deep learning
data analysis
artificial intelligence