Pregnancy outcomes of Fabry disease in Austria (PROFABIA)-a retrospective cohort-study.
Natalja Haninger-VacariuKyra AnastopoulosChristof AignerRaute Sunder-PlassmannConstantin GattererMarkus PonleitnerGere Sunder-PlaßmannAlice SchmidtPublished in: Orphanet journal of rare diseases (2024)
Our cohort-study in women with Fabry disease shows an increase of pain burden during pregnancies and clearly points to an increased risk for preeclampsia, prematurity, and neonates small for gestational age. With a substantial number of high-risk pregnancies, neonatal outcomes are somewhat worse in Fabry disease than in the general public. Thus, we provide valuable data enabling informed decision-making in pregnancy counselling for Fabry disease.
Keyphrases
- pregnancy outcomes
- gestational age
- preterm birth
- replacement therapy
- hypertrophic cardiomyopathy
- healthcare
- birth weight
- chronic pain
- emergency department
- type diabetes
- machine learning
- mental health
- low birth weight
- smoking cessation
- spinal cord injury
- neuropathic pain
- human immunodeficiency virus
- electronic health record
- insulin resistance
- artificial intelligence
- hepatitis c virus
- deep learning
- weight gain
- antiretroviral therapy
- hiv testing