Assessing the role of rare genetic variants in drug-resistant, non-lesional focal epilepsy.
Stefan WolkingClaudia MoreauMark McCormackRoland KrauseMartin Krennnull nullSamuel Frank BerkovicGianpiero L CavalleriNorman DelantyChantal DepondtMichael R JohnsonBobby P C KoelemanWolfram S KunzHolger LercheAnthony G MarsonTerence J O'BrienSlave PetrovskiJosemir W SanderGraeme J SillsPasquale StrianoFederico ZaraFritz ZimprichSanjay M SisodiyaSimon L GirardPatrick CossettePublished in: Annals of clinical and translational neurology (2021)
Our study identifies potential candidate genes for ASM resistance. Our results corroborate the role of rare variants for non-familial NAFE and imply their involvement in drug-resistant epilepsy. Future large-scale genetic research studies are needed to substantiate these findings.