Distribution of MRI-derived T2 values as a biomarker for in vivo rapid screening of phenotype severity in mdx mice.
Emily A WatersChad R HaneyLauren A VaughtElizabeth M McNallyAlexis R DemonbreunPublished in: PloS one (2024)
Use of this rapid, non-invasive, semi-automated MR image segmentation and analysis pipeline has the potential to transform preclinical studies, allowing for pre-screening of dystrophic mice prior to study enrollment to ensure more uniform muscle disease pathology across treatment groups, improving study outcomes.
Keyphrases
- deep learning
- machine learning
- magnetic resonance imaging
- contrast enhanced
- skeletal muscle
- type diabetes
- computed tomography
- high throughput
- stem cells
- high fat diet induced
- adipose tissue
- duchenne muscular dystrophy
- convolutional neural network
- insulin resistance
- human health
- cell therapy
- weight loss
- glycemic control
- wild type