Novel mechanism of cisplatin resistance in head and neck squamous cell carcinoma involving extracellular vesicles and a copper transporter system.

Tatsuo OgawaKisho OnoShoji RyumonHotaka KawaiTomoya NakamuraKoki UmemoriKunihiro YoshidaHideka KanemotoKyoichi ObataNorie YoshiokaTatsuo OkuiKuniaki OkamotoHitoshi NagatsukaSoichiro Ibaragi

Published in: Head & neck (2024)

EVs were involved in the ATP7B-mediated mechanism underlying CDDP resistance. Further clarification of the EV-induced CDDP-resistance mechanism may lead to novel therapeutic strategies for HNSCC.

Keyphrases

high glucose
diabetic rats
oxidative stress
endothelial cells