Periconceptional folate intake influences DNA methylation at birth based on dietary source in an analysis of pediatric acute lymphoblastic leukemia cases and controls.
Eric M NickelsShaobo LiLibby M MorimotoAlice Y KangAdam J de SmithCatherine MetayerJoseph L WiemelsPublished in: The American journal of clinical nutrition (2022)
We identified modest associations between periconceptional folate intake and DNA methylation differing by source, including variation by ALL case status. Hispanic subjects of lower income and education appear uniquely responsive to periconceptional folate supplementation.