Combining rapid diagnostic tests to estimate primary and post-primary dengue immune status at the point of care.
Joseph R BiggsAva Kristy SyJames AshallMarsha S SantosoOliver J BradyMary Anne Joy ReyesMary Ann QuinonesWilliam Jones-WarnerAmadou O TandocNemia L SucalditoHuynh Kim MaiLe Thuy LienHung Do ThaiHien Anh Thi NguyenDang Duc AnhChihiro IwasakiNoriko KitamuraMarnix Van LoockGuillermo Herrera-TaracenaJoris MentenFreya RasschaertLiesbeth Van WesenbeeckSri MasyeniSotianingsih HaryantoBenediktus YohanEva Cutiongco-de la PazLay-Myint YoshidaStephane HueMaria Rosario Z CapedingCarmencita D PadillaR Tedjo SasmonoJulius Clemence R HafallaMartin L HibberdPublished in: PLoS neglected tropical diseases (2022)
We demonstrate how the primary and post-primary DENV immune status of reporting patients can be estimated at the point of care by combining NS1, IgM and IgG RDTs and considering the days since symptoms onset. This framework has the potential to strengthen surveillance operations and dengue prognosis, particularly in low resource settings.