Prognostic significance of immunohistochemical classification utilizing biopsy specimens in patients with extensive-disease small-cell lung cancer treated with first-line chemotherapy and immune checkpoint inhibitors.
Naoki ShijubouToshiyuki SumiTerufumi KuboKenta SasakiTomohide TsukaharaTakayuki KanasekiKenji MurataYoshiko KeiraKotomi TeraiTatsuru IkedaYuichi YamadaHirofumi ChibaYoshihiko HirohashiToshihiko TorigoePublished in: Journal of cancer research and clinical oncology (2024)
Our study highlights the predictive value of IHC-classified subtypes and CD8-positive cell infiltration in estimating outcomes for patients with ED-SCLC treated with chemoimmunotherapy as a first-line therapy. These findings have practical implications for daily clinical assessments and treatment decisions.
Keyphrases
- small cell lung cancer
- emergency department
- single cell
- machine learning
- fine needle aspiration
- cell therapy
- deep learning
- physical activity
- squamous cell carcinoma
- ultrasound guided
- locally advanced
- type diabetes
- radiation therapy
- bone marrow
- mesenchymal stem cells
- adipose tissue
- skeletal muscle
- insulin resistance
- glycemic control
- weight loss