Clinical profiles of treated and untreated adults with hypophosphatasia in the Global HPP Registry.

Kathryn McCrystal DahirLothar SeefriedPriya S KishnaniAnna PetrykWolfgang HöglerAgnès LinglartGabriel Ángel Martos-MorenoKeiichi OzonoShona FangCheryl Rockman-Greenberg

Published in: Orphanet journal of rare diseases (2022)

Along with the more classical skeletal signs and symptoms, pain, muscular, and constitutional/metabolic manifestations are common in adults with HPP, regardless of age of disease onset, highlighting a full spectrum of HPP manifestations.

Keyphrases

chronic pain
replacement therapy
sleep quality
spinal cord
depressive symptoms
postoperative pain