Genome-Wide Association Study Identifies Risk Loci for Cluster Headache.
Emer O'ConnorCarmen FourierCaroline RanPrasanth SivakumarFranziska LieseckeLaura SouthgateAster V E HarderLisanne S VijfhuizenJanice YipNicola GiffinNicholas SilverFayyaz AhmedIsabel C HostettlerBrendan DaviesM Zameel CaderBenjamin S SimpsonRoisin SullivanStephanie EfthymiouJoycee AdebimpeOlivia QuinnCiaran CampbellGianpiero L CavalleriMichail VikelisTim KeldermanKoen PaemeleireEmer KilbrideLou GrangeonSusie LagrataDaisuke DannoRichard TrembathNicholas W WoodIngrid KockumBendik Slagsvold WinsvoldAnna SteinbergChristina SjöstrandElisabet WaldenlindJana VandrovcovaHenry HouldenManjit MatharuAndrea Carmine BelinPublished in: Annals of neurology (2021)
We identified and replicated several genome-wide significant associations supporting a genetic predisposition in cluster headache in a genome-wide association study involving 1,443 cases. Replication in larger independent cohorts combined with comprehensive phenotyping, in relation to, for example, treatment response and cluster headache subtypes, could provide unprecedented insights into genotype-phenotype correlations and the pathophysiological pathways underlying cluster headache. ANN NEUROL 2021;90:193-202.