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Ice recrystallization inhibition mechanism of zwitterionic poly(carboxybetaine methacrylate).

Yanfang ChenXiaojie SuiTiantong ZhangJing YangLei ZhangYou Han
Published in: Physical chemistry chemical physics : PCCP (2023)
Understanding the ice recrystallization inhibition (IRI) mechanism is of fundamental importance for the rational design of novel antifreeze protein mimetics and reducing IR-related damage. In this communication, using quantitive experimental methods and molecular dynamics simulations we demonstrate that zwitterionic poly(carboxybetaine methacrylate) (PCBMA) can serve as a novel IRI-active substance. This work unravels the atomic-level details of the IRI mechanism of zwitterionic antifreeze protein mimetics and provides insight into the development of next-generation antifreeze protein mimetics.
Keyphrases
  • molecular dynamics simulations
  • protein protein
  • amino acid
  • binding protein