Higher frequency of vertebrate-infecting viruses in the gut of infants born to mothers with type 1 diabetes.

Ki Wook KimDigby W AllenThomas BrieseJennifer J CouperSimon C BarryPeter G ColmanAndrew M CotterillElizabeth A DavisLynne C GilesLeonard C HarrisonMark HarrisAveni HaynesJessica L HortonSonia R IsaacsKomal JainWalter I LipkinKelly McGormGrant MorahanClaire MorbeyIgnatius C N PangAnthony T PapenfussMegan A S PennoRichard O SinnottGeorgia SoldatosRebecca L ThomsonPeter VuillerminJohn M WentworthMarc R WilkinsWilliam D RawlinsonMaria E Craignull null

Published in: Pediatric diabetes (2020)

We demonstrate a distinct gut virome profile in infants of mothers with type 1 diabetes, which may influence health outcomes later in life. Higher prevalence and greater number of viruses observed compared to previous studies suggests significant underrepresentation in existing virome datasets, arising most likely from less sensitive techniques used in data acquisition.

Keyphrases

risk factors
electronic health record
low birth weight
big data
gestational age
genetic diversity
case control
rare case
machine learning
preterm infants