Ferulic Acid: A Natural Phenol That Inhibits Neoplastic Events through Modulation of Oncogenic Signaling.
Hardeep Singh TuliAjay KumarSeema RamniwasRenuka CoudharyDiwakar AggarwalManoj KumarUjjawal SharmaNidarshana Chaturvedi ParasharShafiul HaqueKatrin SakPublished in: Molecules (Basel, Switzerland) (2022)
Despite the immense therapeutic advances in the field of health sciences, cancer is still to be found among the global leading causes of morbidity and mortality. Ethnomedicinally, natural bioactive compounds isolated from various plant sources have been used for the treatment of several cancer types and have gained notable attention. Ferulic acid, a natural compound derived from various seeds, nuts, leaves, and fruits, exhibits a variety of pharmacological effects in cancer, including its proapoptotic, cell-cycle-arresting, anti-metastatic, and anti-inflammatory activities. This review study presents a thorough overview of the molecular targets and cellular signaling pathways modulated by ferulic acid in diverse malignancies, showing high potential for this phenolic acid to be developed as a candidate agent for novel anticancer therapeutics. In addition, current investigations to develop promising synergistic formulations are also discussed.
Keyphrases
- cell cycle
- papillary thyroid
- squamous cell
- healthcare
- anti inflammatory
- cell proliferation
- signaling pathway
- public health
- small cell lung cancer
- mental health
- drug delivery
- working memory
- epithelial mesenchymal transition
- pi k akt
- social media
- oxidative stress
- single molecule
- replacement therapy
- induced apoptosis
- essential oil