Correlates of suicidal behaviors and genetic risk among United States veterans with schizophrenia or bipolar I disorder.
Tim B BigdeliPeter B BarrNallakkandi RajeevanDavid P GrahamYuli LiJacquelyn M MeyersBryan R GormanRoseann E PetersonFrederick SaywardKrishnan RadhakrishnanSundar NatarajanDavid A NielsenAnna V WilkinsonAnil K MalhotraHongyu ZhaoMary BrophyYunling ShiTimothy J Oâ LearyTheresa GleasonRonald PrzygodzkiSaiju PyarajanSumitra MuralidharJohn Michael Gazianonull nullnull nullGrant D HuangJohn ConcatoLarry J SieverLynn E DeLisiNathan A KimbrelJean C BeckhamAlan C SwannThomas R KostenAyman H FanousMihaela AslanPhilip D HarveyPublished in: medRxiv : the preprint server for health sciences (2023)
Among individuals with a diagnosed mental illness, a GWAS for SB did not yield any significant loci. Self-reported SB were strongly associated with clinical variables across several EHR domains. Overall, clinical and polygenic analyses point to sequelae of substance-use related behaviors and other psychiatric comorbidities as strong correlates of prior and subsequent SB. Nonetheless, past SB was frequently not documented in clinical settings, underscoring the value of regular screening based on direct, in-person assessments, especially among high-risk individuals.