Endoplasmic reticulum stress enhances the antigen-specific T cell immune responses and therapeutic antitumor effects generated by therapeutic HPV vaccines.
Sung Yong LeeJee Youn OhTae Heung KangHyun Seock ShinMax A ChengEmily FarmerT-C WuChien Fu HungPublished in: Journal of biomedical science (2019)
Our data indicate that 3-BrPA can enhance therapeutic HPV vaccine potency in generating improved antigen-specific immune responses and antitumor effects. These findings have important implications for future clinical translation and provide novel strategies for the treatment of HPV-associated diseases.