Mismatch repair protein mutations in isocitrate dehydrogenase (IDH)-mutant astrocytoma and IDH-wild-type glioblastoma.
Timothy Eric RichardsonRaquel T YokodaOmid RashidipourMeenakshi VijMatija SnuderlSteven BremKimmo J HatanpaaSamuel K McBrayerKalil G AbdullahMelissa UmphlettJamie M WalkerNadejda M TsankovaPublished in: Neuro-oncology advances (2023)
These results suggest that whether present initially or in response to therapy, MMR mutations significantly affect TMB but appear to only influence the clinical outcome in IDH-mutant astrocytoma subsets.