Nanozyme-Augmented Tumor Catalytic Therapy by Self-Supplied H 2 O 2 Generation.

Nanozyme with the "dual identity" of enzymes and nanomaterials is an emerging strategy to mimic natural enzymes in bio-nanotechnology. However, how to improve the nanozyme-based therapeutic efficiency in vivo still remains a challenge. Herein, we fabricated a nanozyme platform (Fe@Fe 3 O 4 @Cu 2- x S, named as MNPs) possessing peroxidase enzyme-like activity and then introduced β-lapachone (La) to assemble an effective nanozyme (LaMNPs) to boost the production of reactive oxygen species and upregulate the level of H 2 O 2 by the released La in an acidic tumor microenvironment. As a proof of concept, LaMNPs were injected intravenously into mice model, resulting in a significant and efficient inhibition of the tumor growth.