FHOD1 is upregulated in glioma cells and attenuates ferroptosis of glioma cells by targeting HSPB1 signaling.

Fan ZhangLixiang WuSongshan FengZijin ZhaoKui ZhangAbhimanyu ThakurZhijie XuQiuju LiangYuanhong LiuWei LiuYuanliang Yan

Published in: CNS neuroscience & therapeutics (2023)

In summary, this study demonstrated that the FHOD1-HSPB1 axis exerts marked regulatory effects on ferroptosis, and might affect the prognosis and therapeutic response in glioma.

Keyphrases

cell death
heat shock protein
heat shock
transcription factor
oxidative stress