Centrifuged supernatants from FNA provide a liquid biopsy option for clinical next-generation sequencing of thyroid nodules.

Wenrui YeBrette HanniganStephanie ZallesMeenakshi MehrotraBedia A BarkohMichelle D WilliamsMaria E CabanillasBeth Edeiken-MonroePeter HuDzifa DuoseIgnacio I WistubaL Jeffrey MedeirosJohn StewartRajyalakshmi LuthraSinchita Roy-Chowdhuri

Published in: Cancer cytopathology (2019)

This study provides evidence that FNA supernatants can be used as a surrogate for thyroid molecular testing to improve diagnostic accuracy in indeterminate nodules, provide prognostic/predictive information, and improve overall patient management.

Keyphrases

fine needle aspiration
ultrasound guided
case report
copy number
ionic liquid
healthcare
gene expression
single molecule