LEAP2 is associated with impulsivity and reward sensitivity depending on the nutritional status and decreases with protein intake in humans.

María F AndreoliAna Luz KrugerAleksandr V SokolovGull RukhPablo N De FrancescoMario PerelloHelgi B Schiöth

Published in: Diabetes, obesity & metabolism (2024)

Increased LEAP2 in participants with OW/OB is associated with behavioural characteristics of obesity. Our results show sexual dimorphism in LEAP2 concentration before and after food intake and highlight the role of LEAP2 in feeding regulation.

Keyphrases

metabolic syndrome
weight gain
type diabetes
insulin resistance
weight loss
mental health
protein protein
body mass index
skeletal muscle
high fat diet induced
amino acid
borderline personality disorder