ROS-dependent palmitoylation is an obligate licensing modification for GSDMD pore formation.

Gang DuLiam B HealyLiron DavidCaitlin WalkerPietro FontanaYing DongPascal DevantRobbins PuthenveetilScott B FicarroAnirban BanerjeeJonathan C KaganJudy LiebermanHao Wu

Published in: bioRxiv : the preprint server for biology (2023)

GSDMD palmitoylation is induced by ROS and required for pore formation.

Keyphrases

cell death
dna damage
reactive oxygen species
oxidative stress