Evaluation of thresholding methods for the quantification of [ 68 Ga]Ga-PSMA-11 PET molecular tumor volume and their effect on survival prediction in patients with advanced prostate cancer undergoing [ 177 Lu]Lu-PSMA-617 radioligand therapy.

Moon-Sung KimRobert SeifertJana FragemannDavid KerstingJacob MurrayFrederic JonskeKelsey L PomykalaJan EggerWolfgang P FendlerKen HerrmannJens Kleesiek

Published in: European journal of nuclear medicine and molecular imaging (2023)

Ga]Ga-PSMA-11-PET. The proposed algorithm-driven thresholding strategy is less arbitrary and less prone to biases than thresholding with predefined values, potentially improving the application of whole-body PSMA-TV as an imaging biomarker.

Keyphrases

pet ct
prostate cancer
positron emission tomography
high resolution
machine learning
radical prostatectomy
single molecule
free survival