Highly Effective Pyroelectric Catalysis for Simultaneous Tumor-Targeted Dynamic Therapy and Gentle Photothermal Therapy by Oxygen-Vacancy-Rich CeO 2 -BaTiO 3 Nanorods.
Ying ChenYushu WangJingyi ShiChunmei GuoLina QiJianhang ZhaoSihan LuoHui ZhouXiaomei LuQu-Li FanPublished in: Advanced healthcare materials (2024)
Pyroelectric nanostructures can effectively generate temperature-mediated reactive oxygen species (ROS) through the pyroelectric effect, providing promise for treating hypoxic tumors; and therefore, the synergistic application of photothermal therapy (PTT) and pyroelectric dynamic therapy (PEDT) presents an intriguing approach for cancer therapy. However, this method still faces challenges in improving pyroelectric catalysis and achieving precise tumor localization. In this study, a nano-heterojunction based on CeO 2 -BaTiO 3 nanorods (IR1061@PCBNR) is reported, which exhibits highly effective pyroelectric catalysis for simultaneous tumor-targeted dynamic therapy and gentle photothermal therapy through the utilization of the rich oxygen vacancies. The oxygen vacancies create active sites that facilitate the migration of pyroelectrically-induced charge carriers, improving charge separation and ROS generation. IR1061@PCBNR also demonstrates high tumor penetration; while, minimizing damage to normal cells. This precise nanomedicine strategy holds great potential for advancing dynamic cancer therapies by overcoming the limitations of conventional approaches.
Keyphrases
- cancer therapy
- reactive oxygen species
- drug delivery
- cell death
- induced apoptosis
- oxidative stress
- stem cells
- bone marrow
- deep learning
- signaling pathway
- squamous cell carcinoma
- visible light
- endothelial cells
- gold nanoparticles
- reduced graphene oxide
- risk assessment
- artificial intelligence
- pi k akt
- squamous cell
- replacement therapy
- childhood cancer