Comparative Genomic Analysis of Pancreatic Acinar Cell Carcinoma (PACC) and Pancreatic Ductal Adenocarcinoma (PDAC)Unveils New Actionable Genomic Aberrations in PACC.

Vaia Florou Andrew Elliott Matthew H Bailey David Stone Kajsa E Affolter Heloisa P Soares Christopher Nevala-Plagemann Courtney L Scaife Phillip Walker Wolfgang Michael Korn Emil Lou Rachna T Shroff Peter J Hosein Ignacio Garrido-Laguna

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

There are major differences between PACC and PDAC, including downregulation of the MAPK signaling pathway, and less stromal cell abundance. In addition, genomic characterization of pure PACC revealed frequent targetable alterations, which can guide patient treatment.

Keyphrases

signaling pathway
copy number
pi k akt
single cell
epithelial mesenchymal transition
cell proliferation
case report
bone marrow
cell therapy
oxidative stress
induced apoptosis
antibiotic resistance genes
microbial community
combination therapy
wastewater treatment