Differential Effects of Type 2 Diabetes Treatment Regimens on Diabetes Distress and Depressive Symptoms in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE): A Randomized Clinical Trial.
Jeffrey S GonzalezIonut BebuHeidi Krause-SteinraufClaire J HoogendoornGladys Crespo-RamosCaroline A PresleyAanand D NaikShihchen KuoMary L JohnsonDeborah J WexlerJill P CrandallAnne E BantleValerie ArendsAndrea L Cherringtonnull nullPublished in: Diabetes care (2024)
Contrary to expectations, this randomized trial found no evidence for a deleterious effect of basal insulin on emotional distress. Glargine lowered diabetes distress modestly at 1 year rather than increasing it. Liraglutide also reduced diabetes distress at 1 year. Results can inform treatment decisions for adults with early T2DM.