Tcf20 deficiency is associated with increased liver fibrogenesis and alterations in mitochondrial metabolism in mice and humans.

Bernat Córdoba-JoverJordi RiberaIrene PortolésElena LecueJuan Rodriguez-VitaLeticia Pérez-SisquésFrancesco MannaraEstel Solsona-VilarrasaCarmen García-RuizJosé C Fernández-ChecaGregori CasalsLaia Rodríguez-RevengaMaría Isabel Álvarez-MoraAna Arteche-LópezAranzazu Díaz de BustamanteRosa CalvoAnna PujolMikel AzkargortaFelix ElortzaCristina MalageladaRoser PinyolJúlia Huguet-PradellPedro Melgar-LesmesWladimiro Jiménez Manuel Morales-Ruiz

Published in: Liver international : official journal of the International Association for the Study of the Liver (2023)

We demonstrated a new role of Tcf20 in fibrogenesis and mitochondria metabolism in mice and showed the association of TCF20 deficiency with fibrosis and metabolic biomarkers in humans.

Keyphrases

high fat diet induced
replacement therapy
cell death
wild type
metabolic syndrome
reactive oxygen species
smoking cessation
endoplasmic reticulum