Synthesis, in vitro and in vivo evaluation of 11C-O-methylated arylpiperazines as potential serotonin 1A (5-HT1A) receptor antagonist radiotracers.
Vidya NarayanaswamiJunchao TongFerdinando FiorinoBeatrice SeverinoRosa SparacoElisa MagliFlavia GiordanoPeter M BloomfieldJaya PrabhakaranJ John MannNeil VasdevKenneth DahlJ S Dileep KumarPublished in: EJNMMI radiopharmacy and chemistry (2020)
Despite efficient radiolabeling, results from PET imaging experiments limit the application of [11C]3 for in vivo quantification of 5-HT1A receptors. Nevertheless, derivatives of compound 3 may provide a scaffold for alternative PET radiotracers with improved selectivity for 5-HT 1A receptors or α1-adrenergic receptors.