EpCAM-independent isolation of circulating tumor cells with epithelial-to-mesenchymal transition and cancer stem cell phenotypes using ApoStream® in patients with breast cancer treated with primary systemic therapy.
Fanny Le DuTakeo FujiiKumiko KidaDarren W DavisMinjeong ParkDiane D LiuWeiguo WuMariana Chavez-MacGregorCarlos H BarcenasVicente ValeroDebu TripathyJames M ReubenNaoto T UenoPublished in: PloS one (2020)
ApoStream was successful in detecting EMT-CTCs among patients after neoadjuvant chemotherapy. However, EMT-/CSC-CTC counts did not correlate with pCR. Due to the small sample size and heterogeneity of this patient population, further study in a larger cohort of molecularly homogeneous patients is warranted.
Keyphrases
- circulating tumor cells
- neoadjuvant chemotherapy
- end stage renal disease
- circulating tumor
- cancer stem cells
- epithelial mesenchymal transition
- newly diagnosed
- locally advanced
- ejection fraction
- chronic kidney disease
- sentinel lymph node
- peritoneal dialysis
- single cell
- case report
- early stage
- smoking cessation
- cell therapy
- cell adhesion