Granulocytic myeloid-derived suppressor cells suppress virus-specific CD8+ T cell responses during acute Friend retrovirus infection.
Malgorzata Drabczyk-PlutaTanja WernerDaniel HoffmannQibin LengLieping ChenUlf DittmerGennadiy ZelinskyyPublished in: Retrovirology (2017)
Our study demonstrates that MDSCs become activated and expand during the acute phase of retrovirus infection. Their suppressive activity on virus-specific CD8+ T cells may contribute to T cell dysfunction and the development of chronic infection.