Tocilizumab as salvage treatment of refractory pulmonary acute graft-versus-host disease.
Alejandra Melgarejo-OrtuñoVicente Escudero-VilaplanaJosé Luis Revuelta-HerreroRebeca Bailen AlmoroxRoberto Collado-BorrellIgnacio Gomez-CenturiónGuillen OarbeascoaMi KwonAna Herranz-AlonsoJose Luis Diez-MartinMaria Sanjurjo-SaezPublished in: Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners (2020)
To the authors' knowledge, this is the first case that describes the effective and safe use of tocilizumab as a rescue treatment in a patient with steroid-refractory pulmonary aGVHD. It showed a rapid onset of action and a favorable safety profile, which could make it an interesting option for the treatment of this potentially fatal complication.