Preclinical targeting of liver fibrosis with a 89 Zr-labeled Fibrobody® directed against platelet derived growth factor receptor-β.

Joey A MunsErik SchootenRychon D J van DasselaarYvet E NoordmanKevin AdamzekArthur C EibergenSebas D PronkSagel CaliNiels J SijbrandiEugen MerkulSabrina OliveiraPaul M P van Bergen En HenegouwenR Bart TakkenbergJoanne VerheijStan F J van de GraafBart A NijmeijerGuus A M S van Dongen

Published in: European journal of nuclear medicine and molecular imaging (2024)

The anti-PDGFRβ Fibrobody® SP02SP26-ABD shows selective and high-degree targeting of activated myofibroblasts in liver fibrosis, and qualifies as a vector for diagnostic and therapeutic purposes.

Keyphrases

liver fibrosis
growth factor
cancer therapy
pet imaging
cell therapy
stem cells
computed tomography
drug delivery
binding protein
pet ct