Meta-analysis of genome-wide DNA methylation and integrative omics of age in human skeletal muscle.

Sarah VoisinMacsue JacquesShanie LandenNicholas R HarveyLarisa M HauptLyn R GriffithsSofiya GanchevaMeriem OuniMarkus JähnertKevin J AshtonVernon G CoffeyJamie-Lee M ThompsonThomas M DoeringAnne GaboryClaudine JunienRobert CaiazzoHélène VerkindtVioletta RaverdyFrançois PattouPhilippe FroguelJeffrey M CraigSara BlocquiauxMartine ThomisAdam P SharplesAnnette SchürmannMichael RodenSteve HorvathNir Eynon

Published in: Journal of cachexia, sarcopenia and muscle (2021)

We provide here the most comprehensive picture of DNA methylation ageing in human skeletal muscle and reveal widespread alterations of genes involved in skeletal muscle structure, development, and differentiation. We have made our results available as an open-access, user-friendly, web-based tool called MetaMeth (https://sarah-voisin.shinyapps.io/MetaMeth/).

Keyphrases

skeletal muscle
dna methylation
genome wide
endothelial cells
insulin resistance
systematic review
gene expression
induced pluripotent stem cells
copy number
single cell
metabolic syndrome