Artificial Metallooxidases from Cyclodextrin Diacids.

Published in: Chemistry (Weinheim an der Bergstrasse, Germany) (2017)

Unprecedented simple artificial metalloenzymes were made from cyclodextrin diacids. Six α- and β-cyclodextrin diacids were prepared and their metal-binding and acid properties were investigated. The diacids formed fairly stable complexes with copper, zinc, and iron, with dissociation constants of 0.4-8×10-4 m. The iron complexes were found to catalyse a Fenton-like oxidation reaction of benzylic alcohols, which displayed Michaelis-Menten catalysis and rate accelerations up to 2700.

Keyphrases

capillary electrophoresis
ionic liquid
hydrogen peroxide
electron transfer
oxide nanoparticles
iron deficiency
wastewater treatment
atomic force microscopy
visible light
binding protein
transcription factor
single molecule
high speed