Essential Hypertension Worsens Left Ventricular Contractility in Systemic Sclerosis.
Valentina MercurioAlicia M HinzeLaura K HummersFredrick M WigleyAmi A ShahMonica MukherjeePublished in: The Journal of rheumatology (2021)
Speckle-derived strain revealed diminished LV contractility in patients with SSc, despite normal LVEF. SSc+HTN+ had more prominent reductions in GLS associated with evidence of LV remodeling and worsened diastolic function. Our findings demonstrate the presence of subclinical LV contractile dysfunction in SSc that is further exacerbated by concomitant HTN, thereby identifying HTN as an important modifiable CV risk factor that should be managed aggressively in this at-risk population.
Keyphrases
- systemic sclerosis
- left ventricular
- smooth muscle
- interstitial lung disease
- blood pressure
- risk factors
- heart failure
- skeletal muscle
- hypertrophic cardiomyopathy
- cardiac resynchronization therapy
- acute myocardial infarction
- mitral valve
- oxidative stress
- aortic stenosis
- rheumatoid arthritis
- transcatheter aortic valve replacement
- percutaneous coronary intervention
- aortic valve