Guiding Treatment Choices for Elderly Patients with Glioblastoma by a Comprehensive Geriatric Assessment.
Carola Lütgendorf-CaucigChristian FreyschlagEva Katharina MaselChristine MarosiPublished in: Current oncology reports (2020)
A set of alleviated therapies, e.g., chemotherapy or radiotherapy alone, hypofractionated radiotherapies with different total doses and variable fractionation regimens as well as hypofractionated radiotherapy with concomitant and adjuvant chemotherapy, have been evaluated during the last years. However, clinicians are still unsure which therapy would fit best to a given patient. Recently, the predictive value of comprehensive geriatric assessment regarding tolerance of chemotherapy and prediction of early mortality has been validated for older GBM patients in a retrospective trial. Thus, it appears that neuro-oncology is now ready for the prospective implementation of geriatric assessment to guide treatment planning for elderly GBM patients.
Keyphrases
- end stage renal disease
- radiation therapy
- ejection fraction
- chronic kidney disease
- locally advanced
- newly diagnosed
- early stage
- peritoneal dialysis
- healthcare
- prognostic factors
- palliative care
- type diabetes
- primary care
- small cell lung cancer
- stem cells
- study protocol
- physical activity
- cardiovascular disease
- bone marrow
- community dwelling
- patient reported
- patient reported outcomes
- risk factors
- hip fracture
- quality improvement
- double blind
- clinical evaluation