A novel cell-free formulation for the treatment of knee osteoarthritis generates better patient-reported health outcomes in more severe cases.

Iván Delgado-EncisoJuan Paz-GarciaJose Valtierra-AlvarezJorge Preciado-RamirezBertha A Olmedo-BuenrostroJosuel Delgado-EncisoJose Guzman-EsquivelCarlos E Barajas-SaucedoGabriel Ceja-EspirituIram P Rodriguez-SanchezMargarita L Martinez-FierroSergio A Zaizar-FregosoDaniel Tiburcio-JimenezJorge E Plata-FlorenzanoBrenda Paz-Michel

Published in: Journal of orthopaedic surgery (Hong Kong) (2021)

BIOF2 generates better patient-reported health outcomes (on pain, stiffness, function, and sleep) in the more severe cases of knee OA.

Keyphrases

patient reported
knee osteoarthritis
cell free
early onset
chronic pain
neuropathic pain
drug delivery
physical activity
circulating tumor
drug induced
sleep quality
spinal cord
spinal cord injury
depressive symptoms
combination therapy
replacement therapy
circulating tumor cells