Identification of Clinically and Pathophysiologically Relevant Rheumatoid Factor Epitopes by Engineered IgG Targets.

Willem J J FalkenburgNienke OskamJana KoersLaurette van BoheemenPleuni Ooijevaar-de HeerGwenny M VerstappenHendrika BootsmaFrans G M KroeseDirkjan van SchaardenburgGertjan WolbinkTheo Rispens

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2020)

Bioengineered IgG targets enable serologic characterization of RF reactivity patterns, and use of this approach appears to reveal patterns associated with ACPA detection and arthritis development in patients with arthralgia. These patterns are able to distinguish RA patients from primary SS patients. This new methodology improves the clinical value of RFs and our understanding of their pathophysiologic processes.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
rheumatoid arthritis
gene expression
sars cov
patient reported outcomes
ankylosing spondylitis
respiratory syndrome coronavirus