Characterization of biological peculiarities of the radioprotective activity of double-stranded RNA isolated from Saccharomyces сerevisiae.
Genrikh S RitterValeriy P NikolinNelly A PopovaAnastasia S ProskurinaPolina E KisaretovaOleg Svyatoslavovich TaranovTatiana D DubatolovaEvgeniya V DolgovaEkaterina A PotterSvetlana S KirikovichYaroslav R EfremovSergey I BayborodinMargarita V RomanenkoMariya I MeschaninovaAliya G VenyaminovaNikolay A KolchanovMikhail A ShurdovSergey S BogachevPublished in: International journal of radiation biology (2020)
Experiments indicate that radioprotective effect of double-stranded RNA is tightly bound to its internalization into hematopoietic stem cells, which further repopulate the spleen parenchyma of irradiated mice. Actively proliferating progenitors form the splenic colonies, which further serve as the basis for restoration of hematopoiesis and immune function and determine the survival of animals received the lethal dose of radiation.