L-plastin Ser5 phosphorylation is modulated by the PI3K/SGK pathway and promotes breast cancer cell invasiveness.

Raquel A C MachadoDunja StojevskiSébastien De LandtsheerPhilippe LucarelliAlexandre BaronThomas SauterElisabeth Schaffner-Reckinger

Published in: Cell communication and signaling : CCS (2021)

Altogether, our results demonstrate that L-plastin Ser5 phosphorylation increases breast cancer cell invasiveness. Being a downstream molecule of both ERK/MAPK and PI3K/SGK pathways, L-plastin is proposed here as a potential target for therapeutic approaches that are aimed at blocking dysregulated signalling outcome of both pathways and, thus, at impairing cancer cell invasion and metastasis formation. Video abstract.

Keyphrases

signaling pathway
pi k akt
papillary thyroid
protein kinase
cell proliferation
squamous cell
oxidative stress
risk assessment
young adults
climate change