Cryo-EM Revolutionizes the Structure Determination of Biomolecules.

Published in: Angewandte Chemie (International ed. in English) (2017)

Freeze frame: The Nobel Prize in Chemistry 2017 was jointly awarded to Jacques Dubochet, Joachim Frank, and Richard Henderson for "developing cryo-electron microscopy (cryo-EM) for the high-resolution structure determination of biomolecules in solution". This Highlight describes how the field of cryo-EM developed from the first transmission electron microscope in 1931 to the sophisticated technique of today.

Keyphrases

electron microscopy
high resolution
solid phase extraction

molecularly imprinted
mass spectrometry

tandem mass spectrometry
high speed

liquid chromatography
solid state