Analysis of acute myeloid leukemia incidence and geographic distribution in Canada from 1992 to 2010 reveals disease clusters in Sarnia and other industrial US border cities in Ontario.

Feras M GhazawiMichelle LeJanelle CyrElena NetchiporoukElham RahmeAkram AlakelAndrei ZubarevMathieu PowellLinda MoreauOsama RoshdySteven J GlassmanDenis SassevilleGizelle PopradiIvan V Litvinov

Published in: Cancer (2019)

These results provide a comprehensive analysis of AML burden in Canada and reveal striking geographic case clustering in industrial Ontario cities and potentially implicate exposure to materials/pollution from these plants as an important risk factor for developing AML in Canada.

Keyphrases

acute myeloid leukemia
heavy metals
allogeneic hematopoietic stem cell transplantation
wastewater treatment
risk assessment
single cell
risk factors
health risk assessment
particulate matter
rna seq
human health
acute lymphoblastic leukemia
air pollution
drinking water