Quantitative T2 MRI Mapping and 12-Month Follow-up in a Randomized, Blinded, Placebo Controlled Trial of Bone Marrow Aspiration and Concentration for Osteoarthritis of the Knees.
Shane A ShapiroJennifer R ArthursMichael G HeckmanJoseph M BesticShari E KazmerchakNancy N DiehlAbba C ZubairMary I O'ConnorPublished in: Cartilage (2018)
BMAC is safe to perform and relieves pain from knee arthritis but showed no superiority to saline injection at 12-month follow-up. MRI cartilage sequences failed to show regenerative benefit with single BMAC injection. The mechanisms of action that led to pain relief remain unclear and warrant further studies.
Keyphrases
- chronic pain
- bone marrow
- ultrasound guided
- mesenchymal stem cells
- contrast enhanced
- magnetic resonance imaging
- pain management
- rheumatoid arthritis
- high resolution
- neuropathic pain
- stem cells
- knee osteoarthritis
- diffusion weighted imaging
- total knee arthroplasty
- anterior cruciate ligament
- study protocol
- cell therapy
- magnetic resonance
- spinal cord injury
- postoperative pain